6-[F18]Fluoro-L-DOPA and Cerebral Blood Flow in Unilaterally MPTP-Treated Monkeys
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چکیده
منابع مشابه
6-[18F]Fluoro-L-DOPA and Cerebral Blood Flow in Unilaterally MPTP-Treated Monkeys
Intravenous administration of 15O-labeled water and 6-[18F]-L-fluorodopa were used to assess abnormal striatal activity in monkeys after long-term recovery of unilateral lesions of the dopaminergic nigro-striatal system induced by the neurotoxin MPTP. PET data were examined in relation to behavioral and biological parameters. Cerebral blood flow and 6-[18F]-L-DOPA uptake were found to be signif...
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BACKGROUND Radiotracer imaging of the presynaptic nigrostriatal dopaminergic system is used to assess disease progression in Parkinson's disease (PD) and may provide a useful adjunct to clinical assessment during therapeutic trials of potential neuroprotective agents. Several clinical trials comparing dopamine agonists to L-DOPA or early vs. late L-DOPA have revealed differences between clinica...
متن کاملGypenosides ameliorate memory deficits in MPTP-lesioned mouse model of Parkinson’s disease treated with L-DOPA
BACKGROUND Previous studies have revealed that gypenosides (GPS) improve the symptoms of anxiety disorders in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned rat model of Parkinson's disease (PD). The present study aimed to investigate the effects of GPS on memory deficits in an MPTP-lesioned mouse model of PD treated with L-3,4-dihydroxyphenylalanine (L-DOPA). METHODS MPTP (30...
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چکیده ندارد.
15 صفحه اولSimilarities and Differences in Cognitive Deficits and Responsiveness to L-Dopa between Aged and MPTP-Treated Cynomolgus Monkeys Tested on the Same Tasks
Cognitive and motor declines are two major geriatric problems often coexisting in older adults. Also, mild cognitive impairment (MCI) is frequently observed in patients with Parkinson’s disease (PD) in addition to motor dysfunction. Amelioration of cognitive deficits, either in patients with PD or in senescence, has proven problematic in the clinic; due, in part, to a poor understanding of the ...
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ژورنال
عنوان ژورنال: Journal of Neural Transplantation and Plasticity
سال: 1993
ISSN: 0792-8483
DOI: 10.1155/np.1993.27